The Walgreens at 86th Street and Cottage Grove Avenue in Chatham is set to close Thursday.
The closures will affect residents in Chicago's predominantly Black and brown neighborhoods.
Walgreens is laying off workers in Chicago.
What is going on with America's drug stores?
Walgreens plans to close about 1,200 locations over the next three years as the drugstore chain seeks to turnaround its struggling U.S. business.
Walgreen's is dropping prices on more than 1,500 items, following similar cost moves by Target and Walmart.