Health officials said the person who died was in their 80s, and they became ill last month.
No other information about the person who died was released.
Humans can get West Nile virus when they are bitten by mosquitoes that contracted the virus by feeding on infected birds.
There have been 11 human cases of West Nile reported in DuPage County this year.
Cook County reported the first human West Nile death in Illinois earlier this month.