CFD said crews responded to a shooting near 61st Street and Prairie Avenue in Washington Park. A woman was taken to St. Bernard Hospital.
Chicago fire officials did not immediately provide the woman's condition or age.
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It was not clear what led up to the shooting involving the bus, or at what time it occurred.
Chicago police did not immediately respond to a request for comment.
A Pace spokeswoman said the shooting happened near one of their buses in the area, but no passengers were on board. The bus operator also was not injured, she said.
The was no vehicle damage reported, either.
This is a developing story; check back with ABC7 Chicago for updates.
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