Rockton, Illinois firefighters responded to the crash in the 8800-block of North Main Road about 4 p.m. Friday, and worked in "treacherous" sub-zero, near white-out conditions, the Rockton Fire Protection District said in a Facebook post.
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Eight vehicles were involved, and no one was seriously injured, Rockton fire officials said. Three people were taken to a local hospital.
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The roadway was closed for some time, officials said.
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The crash remains under investigation.
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There was also a 50-car crash on the Ohio turnpike Friday, in which one person died and multiple people were injured. A tanker overturned in northwest Indiana Friday, as well, that blocked traffic for hours, as freezing temperatures made roadways slick.
Rockton is roughly 100 miles northwest of Chicago, along the Wisconsin border.