Officers responded to a residence in the 100 block of Callan Avenue around 9:20 a.m. and found a 30-year-old woman with "several stab wounds," according to police.
She was transported to St. Francis Hospital, where she was pronounced dead, officials said.
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The Evanston Police Department is investigating with the assistance of the North Regional Major Crimes Task Force Forensic Unit.
No other information was released at this time.