The store near the corner of 115th and Halsted streets is one of 150 Walgreens nationwide that are shutting down.
This leaves the West Roseland community with one less option to fill prescriptions.
SEE MORE: Walgreens is closing 450 locations, including 150 in the US
The company said current patient files will be transferred to the Walgreens at the corner of Ashland and Vermont avenues in Calumet Park.
Walgreens announced the closures in June, as they reported lower earnings compared to last year amid muted consumer spending and a pullback in demand for COVID vaccines.
CNN contributed to this report.