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The incident happened on Saturday at about 9:19 p.m. in the 9300-block of South Bishop Street in Brainerd.
A 15-year-old boy and a 21-year-old woman were inside a car when a woman they knew approached the victims in a silver sedan, Chicago police said.
After a verbal argument, the offender sprayed pepper spray inside the victims' car, according to police.
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The 21-year-old started driving away. The offender followed them in the silver sedan and started shooting into the vehicle.
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The teenage boy was shot in the chest and was sent to the hospital in critical condition.
The 21-year-old woman was shot in the head, and sent to the hospital in critical condition where she later died.
No one is in custody, CPD Area Two Detectives are investigating.
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