Will anyone be able to dethrone the reigning World Series champion Chicago Cubs?
The Cleveland Indians came within one game of beating the Cubs last year, and have loaded up this season in hopes of winning their first title since 1948.
During Sunday Night Baseball's broadcast of the Cubs at the St. Louis Cardinals(8:30 p.m. ET on ESPN), ESPN's Jessica Mendoza, Aaron Boone and Buster Olney will weigh in on the teams with the best chance to take down the Cubs and win the World Series.
Before opening night, make your voice heard and vote on which team poses the biggest challenge to Kris Bryant & Co.
According to our ESPN experts, an Indians vs. Cubs rematch is the most likely World Series scenario, but other teams -- such as the Los Angeles Dodgers, Boston Red Sox, Houston Astros and Washington Nationals -- received votes to win the Fall Classic.
--Isaac Chipps