The shooting happened at about 8 p.m. on the inbound Interstate 90 near North Sacramento Avenue on the city's Northwest Side, Illinois State Police said.
SEE ALSO | Chicago shooting: Woman killed, man critically hurt in Gresham drive-by, police say
The man, 22 years old, was shot in the back and transported to Advocate Illinois Masonic Medical Center in serious condition, the Chicago Fire Department said.
No I-90 lanes were blocked.
Authorities have not said if anyone is in custody. More details about the shooting were not immediately available.
RELATED | Retired Chicago cop shot while trying to stop attempted robbery at currency exchange, police say