The crash happened just before 4 a.m. on the southbound lanes of I-90 near Keeler Avenue in Irving Park, according to state troopers.
ISP said two vehicles crashed on the local lanes, and a person got out of one of the vehicles.
When the person exited the vehicle, they were struck and killed by another vehicle.
Local and express lanes of I-90 southbound were shut down at Keeler Avenue for hours.
All lanes reopened by 8:21 a.m., state troopers said.
No other information was provided.
READ MORE: Metra train strikes, kills pedestrian in Arlington Heights; delays expected