Illinois State Police are investigating the shooting incident that took place at around 1 a.m. southbound near Pulaski, on the city's Southwest Side.
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When ISP District Chicago troopers arrived on the scene, they found a white Jeep across two lanes of traffic with multiple bullet holes, police said.
The driver of the vehicle, a 30-year-old man from Chicago, was wounded in the shooting, according to state police.
A preliminary investigation indicates shots were fired from another vehicle travelling southbound.
The shooting caused the driver to veer of the roadway and crash into a concrete median wall.
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The driver was rushed to Mt. Sinai Hospital in critical condition, police said.
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There were three other passengers in the vehicle at the time, according to police. They include a 23-year-old woman from Oak Lawn, a 22-year-old man from Chicago and a 22-year-old man from Hometown. None were struck by gunfire and did not report any injuries.
There's no word yet on an offender.