The shooting happened around 4:45 p.m. on I-65 in Jasper County, Indiana State Police said.
The driver was driving southbound when they were shot about six miles south of a highway exit near Roselawn and Demotte, police said.
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The victim was transported by medical transport helicopter to a hospital in Indianapolis, police said.
The roadway was closed while the helicopter landed at the scene.
The latest condition of the victim was not immediately known.
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No further information about the shooting was immediately available.