State troopers responded about 12:15 a.m. to westbound I-80 at La Grange Road for a two-car crash involving a wrong-way driver, police said.
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Illinois State Police said a 2011 Kia Optima was traveling eastbound in the westbound lanes of I-80 just past Wolf Road when it struck a 2019 Nissan Versa head-on.
The driver of the Kia and the driver and passenger in the Nissan were killed, police said.
The driver of the Kia has been identified as 28-year-old Rishaunda Buckley of Chicago.
The driver of the Versa has been identified as 30-year-old Amanda Fouche of Aurora and her passenger, 36-year-old Kyle Vance of Aurora.
Fouche was a mother of three, her friend said.
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The westbound lanes were closed just after 1 a.m., and traffic was diverted off to La Grange Road while police investigated.
All lanes reopened about 5:25 a.m.
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Police did not immediately provide additional information about how the crash occurred, the identities of those killed or if anyone else was involved.