People who attend must be fully vaccinated or have a negative COVID-19 test within the past 24 hours.
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So concertgoers who are unvaccinated and attend multiple days will need to get tested daily, organizers said.
Pitchfork also said it recommends attendees wear a mask except when actively eating or drinking.
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Headliners this weekend include Phoebe Bridgers, Saint Vincent and Erykah Badu.
The festival goes from Sept. 9 through 12.