The crash occurred late Sunday night in the outbound lanes of I-90 near Nagle Road. It reportedly involves at least seven vehicles and a box truck.
Traffic was being diverted off the Kennedy Expressway at Bryn Mawr Avenue. The lanes were reopened at around 6:40 a.m. Monday.
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One person was killed in the crash, Illinois State Police said. Authorities have not released information on the person's identity.
Further details on the crash were not immediately available.