Live updates: Trump says 'very good' Iran talks, hints at 'total resolution'

U.S. aircraft dropped "multiple 5,000-pound deep penetrator munitions" on hardened Iranian missile sites along Iran's coastline by the Strait of Hormuz on Tuesday, U.S. Central Command announced.

The bombs are officially "bunker busters" designed to strike at reinforced targets and can also penetrate deep towards a target. Their use against hardened Iranian missile targets along the Strait of Hormuz is part of the ongoing effort to prevent Iran from striking at commercial shipping through the strait.

Many of the larger bombs the U.S. has been dropping are 2,000-pound bombs.

A bomb, known as the Massive Ordnance Penetrator, a 30,000-pound bomb specifically designed to strike at deep underground facilities, was used last June to strike at Iran's underground nuclear facilities.

Two people in Israel are dead following an Iranian missile barrage, according to Magen David Adom, the Israeli emergency response organization.

A man and woman died from "serious shrapnel injuries" in Ramat Gan, near Tel Aviv, the organization said.

Search and rescue crews responded to several sites in central Israel following reports of impacts from Iranian launches, the Israel Defense Forces said.

More than a dozen unmanned MQ-9 Reaper drones have been lost in combat as part of the operations against Iran, two U.S. officials confirmed to ABC News.

The Reaper drones were either lost to Iranian missile fire or were destroyed on the ground by incoming fire.

Reaper drones can be used as reconnaissance aircraft, but they are also equipped with Hellfire missiles used to strike at targets.

The loss of this number of Reapers is indicative of how many of these key unmanned aircraft must be operating as part of the U.S. operations against Iran.

The loss of the drones in the Iran war was first reported by the Wall Street Journal.

Iran's Supreme National Security Council has confirmed that senior official Ali Larijani is dead.

In a statement published by the semi-official Tasnim news agency on Tuesday, the council said Larijani died alongside his son, a security deputy of the secretariat, and several members of his protection team. It did not provide details on how or where the deaths occurred.

Earlier Tuesday, the Israeli minister of defense said Larijani, the head of Iran's Supreme National Security Council, was killed in an overnight attack on Iran.