Portillo's is laying off a large portion of employees at its corporate headquarters in the west suburbs.
The latest reductions follow a round of job cuts in October, when Amazon laid off 14,000 workers.
Mayor Brandon Johnson on Wednesday warned that layoffs could be coming later this year due to the budget that was passed without his support.
The city says more layoffs are on the way, and Harvey's fire department fears for the worst.
A federal judge in San Francisco on Tuesday indefinitely barred the Trump administration from firing federal employees during the government shutdown.
Target, which has been struggling with sales in recent years, announced it is eliminating 1,800 roles or about 8% of the company's global HQ team.