It's a bittersweet moment for fans of the show, who have watched Ryan and Kelly form a special bond and share unforgettable moments with their viewers over the years.
"Before you tell me to stay in my lane - this is my lane. This is my lane," Kelly Ripa said.
The "Live" post-Oscars shows has become a tradition, placing Kelly Ripa and Ryan Seacrest in the middle of movies nominated for the industry's top prize.
The Ryan Seacrest Foundation announced Wednesday that Cohen Children's Medical Center in New York is the recipient of its newest Seacrest Studio.
"You're not just being interviewed by Jesse for the local news. You're actually our grand prize winner. Congratulations!" Kelly Ripa said.
"Live Wire" will be a collection of personal essays about Kelly's childhood, marriage, being a mother, and her career.