The Omicron coronavirus subvariant JN.1 now makes up 44.2% of COVID cases in the United States, according to the CDC.
The omicron offshoot BA.5 carries key mutations that help it escape antibodies generated by vaccines and prior infection.
More than 1.6 million cases of reinfection have been reported across 24 states since data collection began, according to an ABC analysis.
Pfizer released long-awaited data for their vaccine for children 6 months to under 5 years old on Monday morning.
Infectious disease specialists say COVID reinfection is likely to become more and more common as the virus keeps mutating and our vaccines play catch-up.
"This (BA.2.12.1) is now the most transmissible subvariant we have of all," said Dr. Monica Gandhi of UCSF. "It now looks like it's 30% more transmissible than BA.2 alone."