Chicago police said the burglary happened in the 4300-block of North Lincoln Avenue just after 5 a.m.
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The business' overhead garage door was damaged, and thieves took property from inside before fleeing the scene.
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After three other break-ins, the owner is questioning whether he should remain in the city.
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"It's frustrating. It's very frustrating. Nothing has changed, and I don't see anything changing, and I'm asked, over and over again, 'Why are we staying in the city?' And I'm asking that question myself now. Nothing's going to be done. There's no reason to stay here," said Fettes Love and Sieben owner Scott Hoffman.
No one is in custody and Area Three detectives are investigating.
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