"Mongo" has previously returned home following hospital stay in February. The Hall of Famer is battling ALS.
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"The McMichael family is asking for prayers, as Steve was hospitalized today. He is currently undergoing tests," the statement read. "We will update his fans and the media as more information becomes available."
The family issued another statement at 5 p.m. Wednesday, saying McMichael has a urinary tract infection, but he is expected to return home from the hospital Wednesday night.
McMichael was admitted to the ICU last in February.
"He's one tough guy. He's Mongo, and his DNA is different," his wife Misty said in February.
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The 66-year-old went public with an ALS diagnosis three years ago.
McMichael was voted into the Pro Football Hall of Fame in February.
READ MORE | Family, friends celebrate Chicago Bears legend Steve McMichael's election into Hall of Fame