Police said the driver of a black Infiniti sedan was traveling at a high rate of speed in the 3400-block of West Addison Street at about 2:45 a.m. when it ran a red light at Kimball Avenue.
The Infiniti then struck a white Mazda sedan in the intersection, police said. The crash left debris strewn across the intersection.
The male driver of the Mazda was transported to St. Francis Hospital in good condition. The driver of the Infiniti was also transported to St. Francis while two passengers were transported to Illinois Masonic Medical Center with non-life-threatening injuries.
Police said charges in the incident are pending.