Loyola Chicago (5-3) broke a two-game skid that included a 79-65 loss to No. 5 Nevada, and has won six straight and 11 of 12 against crosstown rival UIC (3-5).
Custer was 7-of-13 shooting, and Townes and Krutwig each made six field goals. Cooper Kaifes chipped in 12 points for the Ramblers, who shot 57 percent from the floor.
The Ramblers jumped out with a 24-9 run and built a 37-28 halftime lead. Kaifes scored 11 points and Custer had 10 in the opening half. Loyola Chicago led by double digits for most of the second half.