During a press conference later Monday morning, officials said officers responded to a reported domestic disturbance at 78th and Carpenter streets just after 7:25 a.m.
Police went up to a second floor apartment, observed an altercation and "loud disturbances," and one officer shot a 61-year-old man inside the apartment, CPD officials said.
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The officer then rendered aid to the man, according to CPD. But he later died.
A woman was transported in good condition to a hospital, but it was unclear how she was injured, a Chicago fire official said.
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CPD said the man had a knife, but it was not immediately clear what led up to the fatal shooting.
The patrolman involved is now on desk duty for 30 days.
Civilian Office of Police Accountability investigators were headed to the scene.
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Charles Odum lives across the street from the apartment building and said he had known the man who was killed for two or three years.
"He was a good neighbor," said Odum, 57. "Every time I see him in the morning picking up his paper we'd say hello."
Odum said police often responded to the man's home for disturbances.
"Police always come over here to that unit, always have some type of argument going on whether it's him, a cousin, or whoever stays up there," Odum said.
"I just hate that it happened like this. He's a good person, from what I know, very polite, very talkative," Odum said. "We just chatted about random stuff, life, in the mornings when we saw each other."
Neighbors said the dead man had lived in the apartment building for about four years and did maintenance work there.
Arnita Geder, 57, lives in the same building as the man who died.
Geder described him as "gentle soul." She said he was in a relationship with a woman who'd recently given birth. Geder and other neighbors said they would often hear the couple arguing.
"Him and her used to get into it all the time," Geder said. "She was acting real strange yesterday. Every time you'd say something, she'd snap at you."
A neighbor, Brandy Johnson, also said police had been called numerous times to the house for disputes between the man and his girlfriend.
"Cops have been here dozens of times," Johnson said.
She too said the girlfriend appeared to have mental issues. "She was walking around talking to herself," Johnson said.
Johnson said the man was originally from the West Side and that he'd moved to Gresham with his girlfriend.
It was the second fatal police shooting in Chicago in a month. On Sept. 19, police fatally shot a knife-wielding man after answering a domestic disturbance call in Englewood, authorities said.
About 10:55 a.m., officers responded to a domestic disturbance and encountered a 28-year-old man who was armed with a knife, police said.
An officer shot Turell Brown, who was later died from his wounds, according to officials.
Anyone with information on the incident is asked to call COPA at 312-746-3609 or visit chicagocopa.org.
COPA is responding to an officer-involved shooting in the 006 District. If you or anyone you know may have any information related to this incident, please reach out to our office at 312-746-3609 or visit https://t.co/LqABRQUFLE— COPA (@ChicagoCOPA) October 4, 2021
Sun-Times Media contributed to this report.