The crash occurred in the 6300-block of Illinois Route 83 just before 7 p.m. as a car with six teenagers inside collided with another car, police said.
Police said three teens were ejected from the vehicle and six people were transported to hospitals.
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A 14-year-old was killed in the crash and has been identified to the Cook County Medical Examiner's Office as Madison Harrison. She attended Eisenhower High School in Blue Island.
The cause of the crash is being investigated.