Dr. Baron and fellow researchers tested a drug currently available for adults -- adalimumab (Humira) -- for use in children. "It hopefully stops the inflammatory cascade from creating those signals that cause white blood cells to migrate to the lining of tissues, which starts the inflammation," Dr. Baron said. They are hoping to get the drug FDA approved for use in children as young as five.
"The thing that this medication does that's different from its predecessor is that it allows for a form of the medication that is an injectable form that people can do at home -- almost like an insulin shot to themselves, but even easier than that," Dr. Baron explained. "The predecessor drug mandated an intravenous infusion more than two hours in an infusion center with resuscitation equipment and so forth."
Other drugs available to treat Crohn's disease in children include aminosalicylates, corticosteroids, Immunomodulators and some antibiotics.
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