Amtrak says the derailment near Indianapolis affected the Cardinal line, which normally travels from Cincinnati to Indianapolis, then Chicago.
Due to the derailment, Amtrak passengers were told to get off the train in Cincinnati and take buses either directly to Chicago or to Indianapolis to catch another train.
A fire chief says a train engineer saw a bent rail just before several freight cars derailed and wrecked a bridge over the Big Blue River.
Morristown Fire Chief Steve Davis tells WRTV that the CSX Railroad engineer reported applying the brakes when the derailment happened Wednesday evening about 20 miles southeast of Indianapolis.
No injuries were reported but officials say five of the 16 cars that derailed fell into river. Other cars were left on their sides and sprawled across the tracks.
The steel bridge over the river collapsed. Davis tells WISH-TV that the bridge was nearly 100 years old.
The Associated Press contributed to this report.