A Winter Weather Advisory is in effect from 3 p.m. Tuesday to 9 a.m. Wednesday for Cook, De Kalb, Du Page, Kane, Kendall, La Salle, Lake, Lee, McHenry and Will counties.
A Winter Storm Warning is in effect for Boone, Ogle and Winnebago counties from 4 p.m. Tuesday to 12 p.m. Wednesday.
WATCH: Icy conditions take down bicyclist on Chicago's lakefront path
Snow, which could be heavy at times, is expected to begin falling across Chicagoland in the early evening on Tuesday before transitioning to mixed precipitation, ABC 7 Chicago meteorologist Cheryl Scott said.
Total snow and sleet accumulations of 1 to 5 inches are expected, with the highest snowfall amounts expected along I-88 and north.
WATCH: ABC7 AccuWeather forecast
Ice accumulations of up to two-tenths of an inch are also possible just inland away from the Lake Michigan shore, Scott said.
Drivers should plan for slippery road conditions and periods of sharply reduced visibility late Tuesday afternoon into the early to mid evening, Scott said. The storm could also impact the Wednesday morning commute as well.
Some power outages are possible due to the combined effects of wet snow accumulation, some icing and wind gusts up to 30mph.