Police are reportedly questioning two people in connection with the shooting.
Witnesses said the girl, Aliyah Shell, was on her family's front porch with her parents the 3100 block of South Springfield Avenue when a vehicle approached around 3:40 p.m. Two people pulled out guns and started shooting, police News Affairs Officer Veejay Zala said.
Aliyah was shot multiple times and taken to Mount Sinai Hospital, but doctors were not able to save her.
"I couldn't believe it," said neighbor Reynaldo Navarro. "This guy had a cowboy hat on. It just looked like two normal guys who were saying hello or something. I just heard four gunshots and then a lot of screaming after that.
Navarro rushed to the family's aid.
"The poor thing got hit and she wasstill running around trying to get in the house," Navarro said. That's what is kind of stuck in my mind. After she was hit, she was running around, then she collapsed."
Navarro said it appeared the girl was hit twice, including once in the chest.
"This block better be outraged, and the phones ought to be ringing off the hook to the Chicago Police Department," said Andrew Holmes of No Guns, No Violence. "Turn in every gang member over here that you think is responsible."
Shell's relatives gathered at Mount Sinai but as ABC7 and other news outlets arrived, a Chicago police officer barred media from even the public sidewalk in front of the hospital.
"You can say what you want, I'm not going to debate what's public and what's private," the officer said. "Your first amendment right can be terminated if you're creating a scene or whatever."
Police detained a WGN reporter and a videographer from NBC 5 for a brief period but then released them.
(The Sun-Times Media Wire contributed to this report)