O'Donnell's program is being produced at Harpo studios in the city's West Loop, where Oprah produced her show.
Rosie O'Donnell's first guest Monday will be Russell Brand, a man she says is giving Tom cruise big competition as her favorite actor!
The show's format will include celebrity interviews, games and lifestyle segments.
O'Donnell has just moved into her North Side home, where one of her four children and her new girlfriend will live. She says her family has been enjoying getting to know the city, but she's not fully prepared for a Chicago winter just yet!
"The Rosie Show" her new show airs at 6pm.