Neighbors said one of the victims was elderly and possibly had a disability and would not have easily been able to escape the flames.
It was heartbreaking for neighbors to witness firefighters racing to make entry as smoke poured from the mobile home.
"Oh, blazing, blazing, just shooting out the door, just shooting out the door. I mean, really shooting out the door, nothing but just fire," said neighbor Robert James
James and his daughter, Sheila, could only watch helplessly as firefighters pulled their elderly neighbor from her home.
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"She was unresponsive. When they took her out, they pulled her out, and they laid her on the little ground out there," said neighbor Sheila Ware. "And then the guy, the fire department, he kept saying, bring the ladder, bring the ladder, bring it quick!"
Firefighters arrived around 1:30 p.m. to the Forest View mobile home park near 139th and Division streets.
Neighbors said that elderly resident lived with her adult daughter, and both were seen being pulled from the blaze.
"It's real tough. It's hard for anybody, but especially an elderly woman that's not capable of getting out in an emergency situation like that," said neighbor Stephen Hammer.
"It hit my heart because the fire department, the firefighter, he said to go home and hug your loved ones. That's what he told us," said Ware.
The state fire marshal is now investigating what sparked that fire while neighbors hope for the best.
"It's really tough. It's really tough. I can't even, can't even talk about it," said James.
The Blue Island city administrator said the two victims were taken to Christ Hospital in Oak Lawn, but declined to provide information about their conditions.