A Dodge Journey was traveling northbound on Torrence Avenue when police said it ran a red light and was struck by a semi-trailer traveling east on 130th Street.
The Dodge then spun out and was struck by another semi-trailer traveling east on 130th Street.
The male driver of the Dodge SUV was killed and pronounced dead on the scene, police said.
The driver of the first semi-trailer was transported to Advocate Christ Hospital in serious condition, police said. The driver of the other semi-trailer was not injured.
The intersection of Torrence Avenue and 130th Street is closed as police investigate, which has led to backups on the northbound Bishop Ford Freeway.
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The Chicago Police Major Accidents Investigations Unit and Area Two detectives are investigating.