Just after midnight, the group was standing in the 4600-block of West Monroe Street, when a male approached them and opened fire, Chicago police said.
A 23-year-old woman was struck in the left buttocks and a 25-year-old man was shot in both legs, police said. The woman is in good condition at Stroger Hospital, and the man is in good condition at Mt. Sinai Hospital.
RELATED: West Humboldt Park shooting leaves toddler, man critically wounded, Chicago police say
A 29-year-old woman was struck in the buttocks and was taken to Mt. Sinai Hospital in good condition, police said. An 18-year-old woman was struck in the left leg and was taken to Stroger Hospital, where she is also in good condition.
A fourth woman, 34, was shot in the thigh but refused to go to the hospital, police said. She left the scene in good condition.
No arrests have been made as Area Four detectives investigate.
The early morning mass shooting comes after a toddler and his father were critically injured in a shooting in Chicago's West Humboldt Park neighborhood Tuesday evening.
The child was the 192nd minor to be shot in Chicago so far this year.
A Chicago expressway shooting also shut down the Dan Ryan about 3 a.m. Wednesday near Longwood Manor on the South Side. Illinois State Police said no one was injured.
The Chicago Police Department is counting on significant help from the federal government in the fight against violence.
Chicago Police Superintendent David Brown said President Joe Biden promised to include a law enforcement strike force to work with Chicago police.
Biden also pledged increased efforts to intercept the flow of illegal guns, along with money for violence interruption groups and street outreach workers.
Sun-Times Media contributed to this report.