The No. 8 seed Ramblers lost to the No. 12 seeded Oregon St. Beavers 65-58.
This is the second weekend of the Big Dance after the Ramblers upset #1 seed Illinois.
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Saturday's game was the first meeting between the teams since Dec. 31, 1927, when Loyola won 31-19 in Chicago - and Sister Jean Dolores Schmidt, the Ramblers' beloved 101-year-old chaplain, was still a schoolgirl.
However, not even the fervent prayers of Sister Jean could help Loyola deal with the constantly changing defenses that Oregon State coach Wayne Tinkle rolled out.
Sister Jean is a huge basketball fan who became a global sensation after holding prayer before Loyola games and then rooting from the stands.
Sister Jean has revealed what she will and won't do during games, CNN reported.
"I don't like to talk to anybody when the game is going on and some reporter came up the other day and wanted to interview me, I said 'not during the game,'" she said. "I'll say 'Hi Ramblers, are we ready?' And they say 'Ready, Sister Jean.' And I tell them, 'let us pray and ask God.' We would begin the prayer by saying, 'Good and gracious God, we are about to play - we will say the Oregon State Beavers. We have to watch every player, but here are the ones that you need to look at especially.' I'm not gonna say the numbers now because the Oregon State Beavers might be listening.
The 16 teams will be whittled down to the Elite 8 over the next two days.
The Beavers are headed for their first Elite Eight since 1982 and will play second-seeded Houston or No. 10 seed Syracuse on Monday night for a spot in the Beavers' first Final Four since 1963. Oregon State has never played Syracuse, but it beat Houston in the 1966 West Region semifinal and again in the 2009 CBI Tournament.
CNN and the Associated Press contributed to this article.