The storm hit Puerto Rico six months ago. Some citizens are still without power.
The group from Chicago delivered supplies and money to those affected by the hurricane.
Emanuel toured several hard-hit areas of the island, including the city of Comerio, where he received a warm welcome.
The mayor and Gutierrez also helped cut the ribbon on a newly rebuilt Walgreen's store in Naranjito.
On Sunday, several Chicago Public Schools students plan to leave for Puerto Rico to support relief efforts.