Things, though, soured towards the end as injuries mounted. The former franchise player was traded in 2016 and serenaded with boos upon his return a few months later.
The 30-year-old is hoping Wednesday night began a new chapter in his relationship with his hometown.
Rose had 24 points and eight assists in just his second career game in the United Center against his former team, lifting the Minnesota Timberwolves to a 119-94 victory.
He was cheered loudly throughout by the sellout crowd of 21,852.
"It was great, man," he said. "I didn't expect it to be like this -- overwhelming at some points. You can tell the support is still here."
Rose, the top pick in the 2008 draft, was named the NBA's most valuable player in 2011. He had missed Minnesota's previous game with a sore left ankle.
Because of an assortment of injuries, this was just his fourth career game against the Bulls. He said he got 50 tickets for family and friends.
"I'm happy I didn't change throughout this whole process," he said. "I remained myself. I stayed true to my family. There was a lot of people that jumped off the boat when I was going through things. I (saw) who they were. I know what's fake love and what's real love."
Karl-Anthony Towns had 20 points and 20 rebounds as the Timberwolves won their second straight on the road.
Zach LaVine had 28 points in 26 minutes off the bench and Lauri Markkanen added 16 for Chicago, which had won two straight and three of five before Wednesday. LaVine had missed the previous five games with a sprained left ankle.
"I thought he looked good and aggressive," Bulls coach Jim Boylen said of LaVine. "I like when he drives the ball. He attacked on his first two touches and sometimes that can get you going."
Both Rose and fellow former Bull Taj Gibson received loud ovations when they were announced during player introductions.
Towns scored the game's first basket, but it was Rose who set the tone early. He repeatedly attacked the basket -- showing the form of earlier in his career before the rash of leg injuries -- and had 10 points (5-for-8 shooting) and five assists in the first quarter as Minnesota took a 29-18 lead.
The Timberwolves' advantage was up to 60-37 at halftime.
Rose had 19 points through three quarters as Minnesota took an 83-65 edge into the fourth.
The Bulls pulled within 91-74, but Rose stopped the momentum with a jumper and Dario Saric added a 3-pointer on the next possession for a 96-74 lead with just over seven minutes remaining.
Later in the fourth, the UC crowd started chanting, "MVP... MVP... MVP..." when Rose stepped to the foul line to complete a 3-point play.
"I had to crack a smile a little bit," he said. "It made me reminisce about some of the old days and how grateful I was to be in that position at a young age.
"With the year I'm having, it's very special to come back here and play."
Wolves coach Tom Thibodeau said Rose (averaging 18.7 points on 48.9 percent shooting) is playing at an All-Star level. When asked if he thought that was possible when Minnesota picked up the guard late last season -- after he was waived by Utah -- Thibodeau said:
"I did. The thing that people forget about Derrick is he was MVP at 22. He was still young and that was the biggest thing. I always felt if he got back to being healthy that he could be very productive."
Timberwolves: Gibson finished with 16 points in 26 minutes . G Jeff Teague missed his fifth straight game with a left ankle injury.
Bulls: LaVine had been sidelined since injuring the ankle late in the Bulls' 97-91 loss to the Orlando Magic in Mexico City on Dec. 13. He originally was expected to be sidelined two to four weeks. "Ankle hurt a little bit," he said. "I got tired of sitting down. It still hurts a little bit, but I'll be OK."
Timberwolves: Host the Atlanta Hawks Friday night.
Bulls: At the Washington Wizards Friday night.
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D-Rose ends victorious night with MVP chants in Chicago
Derrick Rose scores 24 points in front of his former home crowd, ending the night with chants of MVP in the Timberwolves' 119-94 win over the Bulls.