Manuel Gonzalez, 29, is charged with first-degree murder and two counts of attempted murder and made his initial court appearance Sunday. He was held on $1 million bond.
Police say he shot and killed 19-year old Miguel Delgado early Saturday during an argument at the corner of Milwaukee and Honore.
Originally, police arrested three men a few blocks away and questioned them Saturday. Authorities also recovered a weapon.
The area is generally considered safe, but some residents say at night, the neighborhood changes.
"Back in 2011, I saw this neighborhood take a turn for the worse. Late-night gun shots; you see a lot of drug trafficking," said area resident Richard Benedict.
This latest shooting happened about a block away from Wicker Park, where a 34year-old man was critically injured last Saturday.