No traffic will be allowed to pass between 8 a.m. and 2 p.m., and all east-west streets will be closed off at the point that they cross State Street between Roosevelt and Wacker.
Sixteen CTA bus routes also will be detoured. Visit www.transitchicago.com for the changed routes.
The McDonald's Thanksgiving Parade steps off at 8 a.m. at Congress and follows State Street to Randolph.