Job creation and economic growth will take center stage.
The two-day meeting will be focused on new, specific, and measurable plans to address challenges in the U.S., particularly through job creation, to help the roughly 13 million Americans currently out of work.
Mayor Rahm Emanuel will welcome Clinton Wednesday morning.
Speakers include U.S. Treasury Secretary Timothy Geithner, Indiana Governor Mitch Daniels, and Mississippi Governor Haley Barbour.
