Sharon Burton, of the 3600-block of West Franklin Blvd., is charged with one count of first-degree murder.
The 32-year-old victim was stabbed in the chest after a fight with his girlfriend, Chicago police say.
Burton is accused of stabbing Terrance Quigley at his home, also in the 3600-block of West Franklin about 3:22 p.m. on Monday, authorities said.
Quigley was pronounced dead at Norwegian-American Hospital at 4:08 p.m., according to the Cook County Medical Examiner's office.
Burton is scheduled to appear in bond court Wednesday.
The Sun-Times Media Wire contributed to this report.