Union members were at CTA stations handing out fliers Thursday.
The schools slated for closure unfairly impact the African-American community, according to the CTU members who protested.
"CPS has an obligation to provide all families and children in every neighborhood with high-quality school options," a Chicago Public Schools spokesperson said. "The fact remains that the District has too many buildings with too few students and we have the responsibility to make decisions to right-size the District so that resources are utilized effectively and in the best interests of our students."
School officials said that more than 100 schools are half-empty because of under-enrollment and they are working to determine which schools to close.
