The store Running For Kicks in Palos Heights hosted the seven-mile benefit run.
Two hundred runners signed up, including more than two dozen who participated in the Boston Marathon.
Some of Monday night's runners say they want to run in support of the victims, no matter how difficult it is.
"Running for the cause, you're training, the people that you knew, the stories of the injured, all sorts of things that go on to keep you going and running strong," said Donna Kase.
Earlier Monday night in the city, fleet feet held a Runners For Boston fun run in Old Town and Lincoln Square.
More than 250 people took part in those runs.