It happened as she was struggling to save her cable network, jet setting across the country and filming her leading role in Lee Daniels' "The Butler."
In an interview with "Access Hollywood" she says she was going from one thing to the next thing and thought, "If I don't calm down, I'm gonna be in serious trouble."
Oprah says it wasn't until an interview with a director, who had a public meltdown, that she realized she was having similar symptoms of a breakdown.