The fire started just before 1 a.m. Fire officials say it sparked inside the three-and-a-half story building in the 3200-block of West Wabansia then spread to at least two buildings next door.
One woman says she woke up to neighbors banging on her door, as the fire spread from home to home.
I was just asleep with my daughter and all of a sudden the fire started from next door. Did you smell smoke? There was a lot of racket. They were breaking into house next door. I turned around to the window and I saw flames. My daughter was next to the window. I just grabbed my daughter and ran out," said resident Jacqueline Uriostegui.
A firefighter who was experiencing chest pains was taken to St. Mary's Hospital in fair to serious condition, and a civilian was also injured and taken to a nearby hospital. That person was in fair to serious condition, as well.
The fire was extinguished by 3 a.m., and the American Red Cross was on the scene helping people displaced by the damage to stay warm and get replacements for any necessary medications.
Sadly, ABC7 Chicago also is told some household pets died in the fire.
The cause and origin of the fire remain under investigation.