Correa, playing for Class A Lancaster, was carried off the field and carted to the clubhouse after sustaining the injury while sliding into third base.
The official nature of Correa's injury has not been disclosed, but the Antelope Valley Press reported that the 19-year-old shortstop may have suffered a broken right fibula.
The 6-foot-4 Correa is batting .325 with six home runs, 57 RBIs and 20 stolen bases in 62 games this season with Lancaster, the Astros' advanced Class A affiliate.
Correa recently was ranked as baseball's No. 2 overall prospect by ESPN Insider Keith Law.
Astros' Top Prospect Suffers Injury
ESPN.com's Christina Kahrl discusses the leg injury suffered by former No. 1 overall draft pick Carlos Correa.