Friends identified two of the victims Sunday night as 25-year-old Amonie Hill and 22-year-old Gia Abgarian of Northeast Philadelphia.
The incident occurred around 2:45 a.m. Sunday on the 8100 block of Torresdale Avenue in the city's Holmesburg section.
Authorities say a black Chevrolet Camaro occupied by the three women was traveling northbound on Torresdale Avenue at a high rate of speed.
After crossing Rhawn Street, the driver lost control and the vehicle spun and slammed into an unoccupied, parked tractor trailer carrying herbicide.
The impact caused the tractor trailer and the passenger car to burst into flames.
"Me and my girlfriend looked right out the window and we just saw a big pile of black smoke," said witness David Anderson. "We ran right out to see."
Authorities tell Action News fuel from the truck ran down Torresdale Avenue where the highway slopes under a freight train bridge, and a second tractor trailer that was parked there also caught on fire.
The three passengers inside of the car that struck the tractor trailer were killed in the fiery crash.
"Witnesses on the scene said that he could hear people screaming from inside the car and attempted to render aid to them, but he couldn't get to the vehicle due to the flames," said Philadelphia Police Capt. Anthony Ginaldi.
"He was in tears. Heartbroken. He tried to do what he could do," said Anderson. "At that point it was just hard to see that."
Police tell Action News arriving officers and firefighters made several attempts to rescue the three occupants, but were pushed back by the intense flames.
"There was a couple rescue attempts, that I understand," said Philadelphia Fire Battalion Chief Michael Senski. "They did an excellent job of stopping the spread of the fire and the spill - the fuel spill and the herbicide spill, containing that to Torresdale Avenue."
A hazmat team from the Philadelphia Fire Department responded to the scene to assess the damage due to the fuel spill, as well as contain a pesticide spill from one of the trucks involved. An additional concern is runoff to the Pennypack Creek, which runs near the accident scene.
Action News viewer Oleg Skywalker sent us video of flames consuming one of the tractor trailers involved.
Sarah Webster came to the scene later in the day after hearing one of her close friends was in the Camaro.
"She was like a sister I always wanted. She was one of my best friends. The only person I ever felt comfortable talking to," said Webster.
Action News spoke to people who live in the neighborhood who say it's not unusual to see people speeding down the street.
"People fly down this road. Nobody drives the speed limit. They're always doing 50, 40 miles an hour down this road, and it's just been a hazard for years and they never do anything about it," said Tim Rentz.
Despite no parking signs, neighbors say truckers often leave their rigs parked overnight.
Paul Definis with the Upper Holmesburg Civic Association says he's working with the City Council, hoping to ban tractor trailers from parking on the neighborhood street.
"It's constant. People are constantly hitting parked cars here because it's dark along here and they just can't see it," said Definis.
"They're always there. I've lived in this neighborhood for 40 years. They're always there," said Marybeth Veneziale.
A stretch of Torresdale Avenue was closed Sunday as Hazmat crews cleaned up herbicide and cable company workers restrung lines.
By evening, a scorched tractor trailer was towed from the scene.
Meanwhile, dozens of the victims' friends gathered for a candlelight vigil.
"She was my best friend," said Ashley Mouhatir, Abgarian's sister-in-law.
"She definitely loved you more than you loved her," said Sam Saitz, Abgarian's friend. "She definitely showed a lot of love all the time."
Police have not publicly identified any of the victims.
They tell Action News they have identified two of the victims. The third victim is being considered a Jane Doe.
Police said they expect to publicly release the names of the victims Monday morning.
The investigation continues into all the circumstances that led to the crash.