The two will be in Chicago tape an episode for Winfrey's show on April 27. It will air on May 2 on ABC7 at 9 a.m.
Obama is already scheduled to be in Chicago this Thursday and Friday, so the Oprah visit will mark his second visit to Chicago in April.
The Oprah Show will end this May after 25 years. The top-rated television talk show airs in 14 countries worldwide.