Dubbed "Flublok," the vaccine is permitted for use among people 18 to 49-years-old to prevent the flu.
The vaccine was created using DNA technology and an insect virus.
The new technology offers the potential for faster start-up of the vaccine manufacturing process in the event of a pandemic, according to the FDA.
Possible side effects include headache, fatigue and muscle aches. However, experts say these symptoms are also typical for conventional vaccines.