Family members say 74-year old Lula Brown, who has Alzheimer's disease, left her home in Flossmoor Thursday to go to an office at 127th and Kedzie, and has not been seen since.
She was driving a 2008 Toyota Highlander.
She is 5-feet-2-inches tall and weighs 190 pounds.
Anyone with information should call Floosmoor Police.