He spent most of his career at the Big 89, WLS-AM.
Lujack was teamed up there with fellow DJ Tommy Edwards. The two were known to their fans as "Uncle Lar' and Lil Tommy."
Lujack's cutting dry wit and almost gravelly voice turned segments, such as animal stories, into must-listen moments.
Jan Jeffries, senior vice president corporate/programming for WLS Radio issued the following statement on Lujack's death: "The passing of Larry is a loss not only to countless friends across Chicagoland, but to hundreds of thousands of loyal listeners who affectionately referred to him as Uncle Lar'. Larry defined WLS. Bigger than life and legendary. He will be missed as a broadcaster, however, even more as a humanitarian with a heart of gold. Larry would want us to celebrate his life and that is the way will honor his passing. God's speed Larry!"
In 2004, Lujack was inducted into the Radio Hall of Fame. According to reports, he had been suffering from esophageal cancer.
Lujack was 73.